Hydrochloric Acid → HCID 117858529, compound

HRID 1486276Notes

Reaction equation

HRID 1486276 reaction equation
C1(C(=[N:14][C:15]([CH3:22])([CH2:18][CH2:19][CH2:20][F:21])[C:16]#[N:17])C2C=CC=CC=2)C=CC=CC=1.[ClH:23]>O1CCCC1.O>[ClH:23].[NH2:14][C:15]([CH3:22])([CH2:18][CH2:19][CH2:20][F:21])[C:16]#[N:17]

Participants

5

Reactant 2

HCID 313Hydrochloric Acid2×HCID 90251300HCID 90251300, compound

Product 1

HCID 117858529HCID 117858529, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

18.94 g (56.62 mmol; 88% purity) of rac-2-[(diphenylmethylene)amino]-5-fluoro-2-methylpentanonitrile from Example 71A were dissolved in 264.6 ml of tetrahydrofuran and 10.2 ml of water, 124.6 ml (62.28 mmol) of hydrogen chloride solution (0.5 N in diethyl ether) were added and the mixture was stirred at room temperature overnight. The reaction solution was admixed with 28.3 ml (56.62 mmol) of hydrogen chloride solution (2 N in diethyl ether) and concentrated by rotary evaporation. The isolated crude product was reacted further directly without further purification.

Workup

  1. concentrationconcentrated by rotary evaporation
  2. customThe isolated crude product
  3. customwas reacted further directly without further purification

Sources & evidence

ORD record
ord-883f4bf0e2034af3bef7ddc7a070c9c5
Source dataset
uspto-grants-2016_08
Patent number
US09422285B2

Reaction notes

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