反应详情

0.50 g (1.01 mmol) of 1-amino-2-[(2,6-difluorobenzyl)oxy]-4-methylpyridinium 2,4,6-trimethylbenzenesulphonate from Example 2A were dissolved in 3.3 ml of DMF, and 229 mg (1.82 mmol) of methyl hex-2-ynoate were added. 251 mg (1.82 mmol) of potassium carbonate were added and the mixture was stirred at RT for 3 h. Subsequently, the mixture was poured onto 24 ml of water and stirred briefly, and the precipitated solids were filtered off, washed with water and dried. 169 mg of the title compound were obtained (42% of theory; 95% purity).

1. stirringstirred briefly
2. filtrationthe precipitated solids were filtered off
3. washwashed with water
4. customdried