Isopropanol → Tetrahydrofuran 2-propanol

HRID 1486456Notes

Reaction equation

HRID 1486456 reaction equation
C[C@@:2]12[C@@H:18]([OH:19])[CH2:17]C[C@H]1[C@H]1[C@@H]([C:6]3C=C[C:9]([OH:20])=[CH:10][C:11]=3CC1)CC2.C(O)(C)C>O1CCCC1>[CH2:10]1[CH2:9][O:20][CH2:6][CH2:11]1.[CH3:17][CH:18]([OH:19])[CH3:2]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 5757Estradiol2×

Product 1

HCID 22597222Tetrahydrofuran 2-propanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

Estradiol, polyethylene-co-vinyl acetate (PEVA) (33% vinyl acetate), and poly-n-butyl methacrylate (PBMA) were combined in equal weight proportions in a solution that was 90% tetrahydrofuran (THF) and 10% isopropyl alcohol (IPA). The resulting solution had a total solids concentration of 40 mg/ml (33% PEVA/33% PBMA/33% estradiol). The resulting solution was below the saturation point for estradiol in a solvent of 90% THF/10% IPA at ambient temperature (approximately 21-22° C.).

Workup

  1. custom(approximately 21-22° C.)

Sources & evidence

ORD record
ord-c28b8e11ece1431dac969e5a37bae125
Source dataset
uspto-grants-2016_08
Patent number
US09427501B2

Reaction notes

Loading…