Toluene → HCID 86605545, compound

HRID 1486457Notes

Reaction equation

HRID 1486457 reaction equation
[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17]C[C@H:15]1[C@H:14]1[C@@H:5]([C:6]3C=C[C:9]([OH:20])=[CH:10][C:11]=3CC1)[CH2:4][CH2:3]2.C1COCC1.C1(C)C=CC=CC=1>C(O)(C)C>[C:2]1([CH3:1])[CH:15]=[CH:14][CH:5]=[CH:4][CH:3]=1.[CH2:10]1[CH2:9][O:20][CH2:6][CH2:11]1.[CH:18]([OH:19])([CH3:2])[CH3:17]

Participants

5

Reactant 3

HCID 1140Toluene3×HCID 5757Estradiol4×HCID 8028Tetrahydrofuran3×

Product 1

HCID 86605545HCID 86605545, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent3×

Procedure

Estradiol was combined with THF. Polyethylenevinylacetate (PEVA), and poly-n-butyl methacrylate (PBMA) was combined with a solution containing eight parts toluene and one part isopropyl alcohol. The estradiol solution was combined with the PEVA/PBMA solution to form a coating solution containing equal weight proportions of estradiol, PEVA, and PBMA and a solvent containing 80% toluene, 10% THF, and 10% isopropyl alcohol, with a total solids concentration of 40 mg/ml (33% PEVA/33% PBMA/33% estradiol). The resulting solution was approximately at the saturation point for estradiol in a solvent of 80% toluene, 10% THF, and 10% isopropyl alcohol at ambient temperature (approximately 21-22° C.).

Workup

  1. customto form a coating solution
  2. custom(approximately 21-22° C.)

Sources & evidence

ORD record
ord-b107ba672673417ba02431390d3a65e9
Source dataset
uspto-grants-2016_08
Patent number
US09427501B2

Reaction notes

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