Sodium Hydroxide → HCID 117834224, compound

HRID 1486467Notes

Reaction equation

HRID 1486467 reaction equation
[OH-].[Na+].O.O.[I:5][C:6]1[CH:7]=[C:8]([CH:15]=[C:16]([I:19])[C:17]=1[OH:18])[CH2:9][C@@H:10]([C:12]([OH:14])=[O:13])[NH2:11].S([O-])([O-])(=O)=O.[Cu+2:25]>O>[Cu:25].[I:5][C:6]1[CH:7]=[C:8]([CH:15]=[C:16]([I:19])[C:17]=1[OH:18])[CH2:9][C@@H:10]([C:12]([OH:14])=[O:13])[NH2:11]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 24462Copper SulfateHCID 27243303,5-Diiodo-L-tyrosine dihydrate

Product 1

HCID 117834224HCID 117834224, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
22.5 °C

Procedure

RBF was charged with 1200 ml of water and 15.01 gms of sodium hydroxide at 20-25° C. and stirred to get a clear solution. 100 gms of 3,5-Diiodotyrosine dihydrate was added and to the above mixture and stirred for an hour to get a clear solution. Copper sulphate solution (35.94 gms dissolved in 225 ml of water at 40° C.) was then added into the reaction mixture over a period of 1 hr and maintained at 20-25° C. for 1 hr. The resultant reaction mixture is filtered and washed with 1500 ml of DM water and dried under vacuum at 55-60° C. to get 95 gms of 3,5-Diiodo L-Tyrosine copper complex. The purity of obtained complex is NLT 97% with yield of 93-98%.

Workup

  1. customto get a clear solution
  2. stirringstirred for an hour
  3. customto get a clear solution
  4. customThe resultant reaction mixture
  5. filtrationis filtered
  6. washwashed with 1500 ml of DM water
  7. customdried under vacuum at 55-60° C.
  8. customto get 95 gms of 3,5-Diiodo L-Tyrosine copper complex

Sources & evidence

ORD record
ord-9a8e336528f44c6586b7de4297ef9f17
Source dataset
uspto-grants-2016_08
Patent number
US09428444B2

Reaction notes

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