Hydrochloric Acid → L-Pyroglutamic Acid

HRID 1486475Notes

Reaction equation

HRID 1486475 reaction equation
[NH2:1][C@H:2]([C:8]([O-:10])=[O:9])[CH2:3][CH2:4][C:5](O)=[O:6].[Na+].Cl>>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:8]([OH:10])=[O:9]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 23672308Sodium Glutamate

Product 1

HCID 7405L-Pyroglutamic Acid

Procedure

20 g of monosodium glutamate (Aldrich) was mixed with 11 mL of HCl 32% and the pH was adjusted to about 2.5 (using HCl). The mixture was heated to above 100° C. in an autoclave for 10 hours. Then, the solution was evaporated to dryness to obtain the L-pyroglutamic acid.

Workup

  1. temperatureThe mixture was heated to above 100° C. in an autoclave for 10 hours
  2. customThen, the solution was evaporated to dryness

Sources & evidence

ORD record
ord-55b4d64ec5c24a1282320967691fe037
Source dataset
uspto-grants-2016_08
Patent number
US09428458B2

Reaction notes

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