HCID 67085866, compound → HCID 18353825, compound

HRID 1486650Notes

Reaction equation

HRID 1486650 reaction equation
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([O:12]CC2C=CC=CC=2)=[O:11])=[N:8][CH:9]=1)([CH3:3])=[CH2:2]>CO.[OH-].[OH-].[Pd+2]>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]([OH:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])=[CH2:2]

Participants

4

Reactant 1

HCID 67085866HCID 67085866, compound

Product 1

HCID 18353825HCID 18353825, compoundYield 95.6%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A solution of benzyl 5-isopropenylpicolinate (1.27 g, 5 mmol) in MeOH (25 mL) was subjected to hydrogenation with 20% Pd(OH)2/C (200 mg) with a H2 balloon for 2 h. The product 5-isopropenylpicolinic acid (780 mg) was obtained by filtration and concentration.

Sources & evidence

ORD record
ord-ec108bedbd4044bd8d5bcf263e895630
Source dataset
uspto-grants-2016_08
Patent number
US09428475B2

Reaction notes

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