Tetrahydrofuran → tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)piperidine-1-carboxylate

HRID 148666Notes

Reaction equation

HRID 148666 reaction equation
[C:46]([CH3:47])([CH3:48])([CH3:49])[O:50][C:51](=[O:52])[N:53]1[CH2:54][CH2:55][CH:56]([OH:59])[CH2:57][CH2:58]1.[O:20]=[C:21]([O:22][CH:23]([CH3:24])[CH3:25])[N:26]=[N:27][C:28]([O:29][CH:30]([CH3:31])[CH3:32])=[O:33].[O:60]1[CH2:61][CH2:62][CH2:63][CH2:64]1.[OH:34][c:35]1[cH:36][cH:37][c:38]2[c:43]([cH:44]1)[NH:42][C:41](=[O:45])[CH2:40][CH2:39]2.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[O:34]([c:35]1[cH:36][cH:37][c:38]2[c:43]([cH:44]1)[NH:42][C:41](=[O:45])[CH2:40][CH2:39]2)[CH:56]1[CH2:55][CH2:54][N:53]([C:51]([O:50][C:46]([CH3:47])([CH3:48])[CH3:49])=[O:52])[CH2:58][CH2:57]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 27857587-Hydroxy-3,4-dihydrocarbostyril

Product 1

HCID 57575910tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7a5576b8ce6c4d70a3d7b77102664504
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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