Hydrochloric Acid → 5-Fluoro-pyridine-2-carboxylic acid (3-formyl-phenyl)-amide

HRID 1486745Notes

Reaction equation

HRID 1486745 reaction equation
Cl.[O:2]1CCO[CH:3]1[C:7]1[CH:8]=[C:9]([NH:13][C:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][N:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1>>[CH:3]([C:7]1[CH:8]=[C:9]([NH:13][C:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][N:17]=2)=[O:15])[CH:10]=[CH:11][CH:12]=1)=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 1317368155-Fluoro-pyridine-2-carboxylic acid (3-[1,3]dioxolan-2-yl-phenyl)-amide

Product 1

HCID 1138923265-Fluoro-pyridine-2-carboxylic acid (3-formyl-phenyl)-amide

Procedure

The title compound is prepared by treatment with HCl 10% of 5-fluoro-pyridine-2-carboxylic acid (3-[1,3]dioxolan-2-yl-phenyl)-amide: LC-MS A: tR=0.79 min; [M+H]+=245.05.

Sources & evidence

ORD record
ord-0bc0f52ab6734b1c92eca57ec738a94d
Source dataset
uspto-grants-2016_08
Patent number
US09428456B2

Reaction notes

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