Triethylsilane → HCID 16792092, compound

HRID 1487123Notes

Reaction equation

HRID 1487123 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=2)=[O:9])[CH2:4][CH2:3]1.C([SiH](CC)CC)C>CO.[Pd]>[NH2:16][C:12]1[CH:11]=[C:10]([C:8]([N:5]2[CH2:4][CH2:3][CH:2]([OH:1])[CH2:7][CH2:6]2)=[O:9])[CH:15]=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 12052TriethylsilaneHCID 9245646HCID 9245646, compound

Product 1

HCID 16792092HCID 16792092, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a stirred solution of (4-hydroxypiperidin-1-yl)(3-nitrophenyl)methanone (1 g, 4.00 mmol) and Pd—C (10%, 0.425 g,) in Methanol (10 ml) was added triethylsilane (3.19 ml, 19.98 mmol) dropwise at room temperature. The reaction mixture was filtered through celite bed. The filtrate was concentrated under vacuum to give the title compound. (0.8 gm)

Workup

  1. filtrationThe reaction mixture was filtered through celite bed
  2. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-115be414f9c045d080c20f54f1b16433
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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