Lithium hydroxide, monohydrate → HCID 20985784, compound

HRID 1487147Notes

Reaction equation

HRID 1487147 reaction equation
[CH3:1][C:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].O[Li].O>O1CCCC1.CO.O>[CH3:8][C:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-:18])=[O:17])[CH:11]=1)([CH3:1])[C:3]([OH:5])=[O:4]

Participants

6

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 22060504Ethyl 2-methyl-2-(3-nitrophenoxy)propanoate

Product 1

HCID 20985784HCID 20985784, compoundYield 86.1%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The mixture of ethyl 2-methyl-2-(3-nitrophenoxy)propanoate (3.5 g, 13.82 mmol) and LiOH.H2O (2.320 g, 55.3 mmol) in Tetrahydrofuran (7 ml), MeOH (7 ml) and Water (7 ml) was stirred at room temperature for 4 hr. The reaction mixture was concentrated under vacuum and the residue was neutralised with 1N HCl, solid separated was filtered and treated with pentane to afford the title product (2.68 g).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customseparated
  3. filtrationwas filtered
  4. additiontreated with pentane

Sources & evidence

ORD record
ord-a6e37d4cc0fb459797635ab53107b773
Source dataset
uspto-grants-2016_08
Patent number
US09428499B2

Reaction notes

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