反应详情

To a solution of 3-nitrobenzoyl chloride (4.5 g, 24.25 mmol) in THF (30 ml) was added 1-methylpiperazine (8.50 g, 85 mmol). The reaction was stirred for 20 min at room temperature. The reaction mixture was diluted with 50 mL water and extracted with ethyl acetate (2×100 mL). The combined organic layer was washed with brine (50 mL). The brine was back extracted with ethyl acetate (2×50 mL) and all the organic layers were combined, dried over magnesium sulphate, filtered, and concentrated under vacuum give the title product (5.2 g).

1. extractionextracted with ethyl acetate (2×100 mL)
2. washThe combined organic layer was washed with brine (50 mL)
3. extractionThe brine was back extracted with ethyl acetate (2×50 mL) and all the organic layers
4. dry with materialdried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated under vacuum