Urea → HCID 178470753, compound

HRID 1487170Notes

Reaction equation

HRID 1487170 reaction equation
ClC1N=C(Cl)C2CCN(CC3C=CC(OC)=CC=3)C=2N=1.[CH:21]([C:33]([O:35]CC)=O)([C:28]([O:30]CC)=O)[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24].[NH2:38][C:39]([NH2:41])=[O:40]>>[OH:40][C:39]1[N:41]=[C:28]([OH:30])[C:21]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:33]([OH:35])[N:38]=1

Participants

4

Reactant 3

HCID 1176UreaHCID 81961Triethyl ethane-1,1,2-tricarboxylateHCID 866996702,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 178470753HCID 178470753, compoundYield 52.4%

Procedure

According to General Protocol I, 2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was prepared from triethyl ethane-1,1,2-tricarboxylate (10 g, 41 mmol) and urea (2.44 g, 41 mmol), and isolated as a pale-yellow solid (4.6 g, yield 35%).

Sources & evidence

ORD record
ord-871773f941e34ba48642bb99c940ecc2
Source dataset
uspto-grants-2016_08
Patent number
US09428508B2

Reaction notes

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