反应详情

4-(3-(1,3-Dioxolan-2-yl)-4-nitrophenyl)morpholine (15.9 g, 56.7 mmol) was dissolved in a mixture of acetone and water (100 mL/100 mL). Then p-toluenesulfonic acid (2.0 g) was added and the mixture was heated to reflux for 4 hours. Ethyl acetate was added and the organic phase was washed with saturated sodium bicarbonate and brine, and then dried over anhydrous sodium sulfate, evaporated to afford the crude product 5-morpholino-2-nitrobenzaldehyde, which was used for the next step without purification.

1. temperaturethe mixture was heated
2. temperatureto reflux for 4 hours
3. washthe organic phase was washed with saturated sodium bicarbonate and brine
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated