Isopropylamine → HCID 90161040, compound

HRID 1487269Notes

Reaction equation

HRID 1487269 reaction equation
[Br:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>CN1C(=O)CCC1.O>[Br:1][C:2]1[N:3]=[C:4]([NH:16][CH:13]([CH3:15])[CH3:14])[C:5]2[N:6]([C:8]([CH3:11])=[N:9][N:10]=2)[CH:7]=1

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 86719150HCID 86719150, compound

Product 1

HCID 90161040HCID 90161040, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
80 °C

Procedure

6-bromo-8-chloro-3-methyl-[1,2,4]triazolo[4,3-a]pyrazine J-1 (30.00 g; 121.2 mmol), isopropylamine (14.30 g; 242.44 mmol) and hünigbase (17.20 g; 133.33 mmol) are dissolved in 150 ml NMP and are stirred for 2 hours at 80° C. The reaction mixture is diluted with water and extracted with EtOAc. The organic layer is separated and dried over MgSO4 and evaporated to dryness.

Workup

  1. extractionextracted with EtOAc
  2. customThe organic layer is separated
  3. dry with materialdried over MgSO4
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-7625714b3e724b45b64374ae5950ddaa
Source dataset
uspto-grants-2016_08
Patent number
US09428513B2

Reaction notes

Loading…