反应详情

Into a 100-mL round-bottom flask, was placed a solution of tert-butyl 4-(4-ethynylphenyl)piperidine-1-carboxylate (compound 76.3, 1.0 g, 3.5 mmol) in ethyl acetate (20 mL). Hydrogen chloride (g) was introduced by bubbling through the solution and the resulting solution was stirred for 1 hour at room temperature. The solids that formed were collected by filtration and washed with hexanes (3×10 mL) to yield the title compound as a brown solid (630 mg, 81%).

1. customInto a 100-mL round-bottom flask, was placed
2. customby bubbling through the solution
3. customThe solids that formed
4. filtrationwere collected by filtration
5. washwashed with hexanes (3×10 mL)