Chlorosuccinimide → HCID 178478292, compound

HRID 1488197Notes

Reaction equation

HRID 1488197 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([C:7]2[CH:11]=[CH:10][NH:9][N:8]=2)[CH2:3][CH2:2]1.C1C(=O)N([Cl:19])C(=O)C1>O1CCCC1>[Cl:19][C:11]1[C:7]([CH:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[N:8][NH:9][CH:10]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 178419959HCID 178419959, compound2×

Product 1

HCID 178478292HCID 178478292, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of 3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole (compound 294.2, 3.5 g, 23.0 mmol) in tetrahydrofuran (20 mL) was added NCS (3.4 g, 25.4 mmol). The reaction mixture was stirred overnight at 40° C. The resulting mixture was concentrated under reduced pressure. This resulted in 4.75 g (crude) of the title compound as a light yellow solid.

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ee460fc7764f442fa45fa380b605ac24
Source dataset
uspto-grants-2016_08
Patent number
US09428502B2

Reaction notes

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