Sodium Sulfite → Sodium 4-benzyloxyphenethyl sulfonate

HRID 1488337Notes

Reaction equation

HRID 1488337 reaction equation
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][CH2:14]Br)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:18]([O-:21])([O-:20])=[O:19].[Na+:22].[Na+]>C(O)(C)(C)C.O>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([CH2:13][CH2:14][S:18]([O-:21])(=[O:20])=[O:19])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+:22]

Participants

5

Reactant 2

HCID 24437Sodium SulfiteHCID 166388271-(Benzyloxy)-4-(2-bromoethyl)benzene

Product 1

HCID 86751366Sodium 4-benzyloxyphenethyl sulfonate

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6386tert-ButanolSolvent

Procedure

A mixture of 4-benzyloxyphenethyl bromide (11.8 g) and sodium sulfite (8.91 g) in tert-butyl alcohol (40 ml) and water (80 ml) is heated at reflux for 40 hours, cooled to room temperature, filtered and the solid washed with water and ether to give sodium 4-benzyloxyphenethyl sulfonate.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 40 hours
  3. filtrationfiltered
  4. washthe solid washed with water and ether

Sources & evidence

ORD record
ord-124122ce245f4bb1baab17b15b92627f
Source dataset
uspto-grants-1997_10
Patent number
US05674482

Reaction notes

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