Tetrahydrofuran → 2-(4-Chloro-phenyl)-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridine

HRID 148869Notes

Reaction equation

HRID 148869 reaction equation
[Br:7][c:8]1[cH:9][cH:10][c:11](-[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[n:12][cH:13]1.[C:1](=[O:2])([O-:3])[O-:4].[C:21](#[CH:22])[c:23]1[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][CH2:33][CH2:34]2)[cH:35][cH:36]1.[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[Cs+:5].[Cs+:6].[Cu:42][I:43]>>[c:8]1([C:22]#[C:21][c:23]2[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]3[CH2:31][CH2:32][CH2:33][CH2:34]3)[cH:35][cH:36]2)[cH:9][cH:10][c:11](-[c:14]2[cH:15][cH:16][c:17]([Cl:20])[cH:18][cH:19]2)[n:12][cH:13]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 131283835-Bromo-2-(4-chlorophenyl)pyridineHCID 859698151-[2-(4-Ethynyl-phenoxy)-ethyl]-pyrrolidine

Product 1

HCID 598359092-(4-Chloro-phenyl)-5-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylethynyl]-pyridine

Sources & evidence

ORD record
ord-bc284ad4a70641f7ab85bfc6056ec916
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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