Hydrochloric Acid → HCID 22877979, compound

HRID 1488710Notes

Reaction equation

HRID 1488710 reaction equation
[ClH:1].C(OC([N:9]([CH:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:19]=2[O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:14]1)[CH2:10][CH2:11][CH3:12])=O)CCC>C(OCC)(=O)C>[ClH:1].[CH2:10]([NH:9][C@H:13]1[CH2:22][CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[C:18]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C:19]=2[O:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:14]1)[CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86751376HCID 86751376, compound

Product 1

HCID 22877979HCID 22877979, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A solution of HCl in ethyl acetate (13% w/v) (250 ml) was added to a solution of (S)-N-t.butoxycarbonyl-N-propyl-5,6-di(phenylmethoxy)-1,2,3,4-tetrahydro-2-naphthylamine (23 g; 45.8 mmoles) in ethyl acetate (100 ml), under stirring at room temperature.

Sources & evidence

ORD record
ord-4b5e487f245f4e438c6f644350ecf81d
Source dataset
uspto-grants-1997_10
Patent number
US05674909

Reaction notes

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