反应详情

(Z)-1-(3-Amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-ethene (1.5 g, 4.76 mmols), 2.1 g (5.7 mmols) of Fmoc-L-Ser(Ac), 1.2 g (5.7 mmols) of DCC and 0.87 g (5.7 mmols) of HOBt.H2O were dissolved in 30 ml of N,N-dimethylformamide, and the mixture was reacted at room temperature for 5 hours. The reaction mixture was diluted with ethyl acetate, then filtered and concentrated. The product was purified through silica-gel column chromatography (mixture of ethyl acetate and hexane at a ratio by volume of 1:2) to produce 1.96 g of the final product in a yield of 61.8%.

1. customthe mixture was reacted at room temperature for 5 hours
2. filtrationfiltered
3. concentrationconcentrated
4. customThe product was purified through silica-gel column chromatography (
5. additionmixture of ethyl acetate and hexane at a ratio by volume of 1:2)