反应详情

First, 4.849 g of 4-(4-oxo-4H-pyridin-1-yl)-1,2-phenylenediamine and 2.402 g of oxalic acid were added to 60 ml of 4N hydrochloric acid. The mixture was refluxed by heating for 2.5 hours in a nitrogen atmosphere. After the mixture was cooled, precipitated crystals were filtered and recrystallized with dimethylformamide to give 4.786 g of 6-(4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione.

1. temperatureThe mixture was refluxed
2. temperatureby heating for 2.5 hours in a nitrogen atmosphere
3. temperatureAfter the mixture was cooled
4. customprecipitated crystals
5. filtrationwere filtered
6. customrecrystallized with dimethylformamide