Hydrochloric Acid → HCID 86753092, compound

HRID 1489016Notes

Reaction equation

HRID 1489016 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH:7]([N:12]3[CH:16]=[CH:15][N:14]=[C:13]3[C:17]([NH2:19])=[O:18])[C:8]2=O)=[CH:4][CH:3]=1.Cl>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:6][C:7]3[N:12]4[CH:16]=[CH:15][N:14]=[C:13]4[C:17](=[O:18])[NH:19][C:8]=3[C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22903634HCID 22903634, compound

Product 1

HCID 86753092HCID 86753092, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure is carried out as in Example 1 but starting with 1 g of 1-(6-chloro-1-oxo-2-indanyl)imidazole-2-carboxamide, a total of 75 ml of methanol and 15 ml of 12N aqueous hydrochloric acid solution. 0.4 g of 7-chloro-5H, 10H-imidazo [1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride is obtained which decomposes without melting above 300° C. [NMR spectrum: (300 MHz; DMSO-d6 ; δ in ppm): 4.12 (s, 2H: --CH2-- in position 10); 7.44 (dd, J=8 and 1 Hz 1H: --H8); 7.66 (d, J=8 Hz, 1H: --H9); 7.95 and 8.25 (2s broad, 1H each: --H of imidazole); 8.05 (d, j=1 Hz, 1H: --H6); 12.97 (unresolved complex, 1H: --CONH--)].

Sources & evidence

ORD record
ord-7e63dfa25d9a4fcdbd467b6165f6f9c4
Source dataset
uspto-grants-1997_10
Patent number
US05677306

Reaction notes

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