2-Chloro-1,3-oxazole → HCID 22099715, compound

HRID 1489082Notes

Reaction equation

HRID 1489082 reaction equation
[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][N:8]=1)=[O:5].O1C=CN=C1[Cl:25]>CN(C)C=O.ClCCl>[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:25])=[O:12])=[CH:9][N:8]=1)=[O:5]

Participants

5

Reactant 2

HCID 133710742-Chloro-1,3-oxazoleHCID 22100000HCID 22100000, compound

Product 1

HCID 22099715HCID 22099715, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

To a suspension of 6-(2-methylbenzoylamino)nicotinic acid (0.3 g) in dimethylformamide (0.5 ml) and dichloromethane (2.5 ml) is added dropwise oxazolyl chloride (0.2 ml), and the mixture is stirred at room temperature for 2 hours. The mixture is evaporated under reduced pressure to remove the solvent to give 6-(2-methylbenzoylamino)nicotinoyl chloride.

Workup

  1. customThe mixture is evaporated under reduced pressure
  2. customto remove the solvent

Sources & evidence

ORD record
ord-3f726e84d5534d528eb64149da3cdc36
Source dataset
uspto-grants-1997_10
Patent number
US05677299

Reaction notes

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