Hydrochloric Acid → 4,5,6,7-Tetrahydro-1H-benzo(d)imidazole-5-carboxylic acid hydrochloride

HRID 1489150Notes

Reaction equation

HRID 1489150 reaction equation
[N:1]1[C:5]2[CH2:6][CH2:7][CH:8]([C:10]([O:12]CC)=[O:11])[CH2:9][C:4]=2[NH:3][CH:2]=1.[ClH:15]>>[ClH:15].[N:1]1[C:5]2[CH2:6][CH2:7][CH:8]([C:10]([OH:12])=[O:11])[CH2:9][C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21222281Ethyl 4,5,6,7-tetrahydro-1H-benzo[d]imidazole-6-carboxylate

Product 1

HCID 532310384,5,6,7-Tetrahydro-1H-benzo(d)imidazole-5-carboxylic acid hydrochloride

Procedure

A 0.3 g portion of this ethyl (+)-4.5,6,7-tetrahydrobenzimidazole-5-carboxylate was dissolved in 2 ml of 6N hydrochloric acid and refluxed for 1.5 hours, and then evaporated to dryness under reduced pressure to obtain 4,5,6,7-tetrahydrobenzimidazole-5-carboxylic acid hydrochloride with the optical rotation indicated below. mp: 245°-248° C.

Workup

  1. temperaturerefluxed for 1.5 hours
  2. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-03ee7c386b1c427d83ca0571a43337fd
Source dataset
uspto-grants-1997_10
Patent number
US05677326

Reaction notes

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