反应详情

A 100 mg portion of the 5-[(3-phenylindolin-1-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole produced in the preferred embodiment 1 was dissolved in 3 ml ethanol, and 0.4 ml of 4N hydrogen chloride solution in ethyl acetate was added under ice cooling. The solution was concentrated under reduced pressure to obtain a partially oily residue. After adding 5 ml of ethyl acetate thereto and stirring, the insoluble portion was collected by filtration to obtain the 5-[(3-phenylindolin-1-yl)carbonyl]-4,5,6,7-tetrahydrobenziamidazole hydrochloride (compound 2) listed in the above heading.

1. concentrationThe solution was concentrated under reduced pressure
2. customto obtain a partially oily residue
3. filtrationthe insoluble portion was collected by filtration