Hydrazine hydrate (1:1) → HCID 22903654, compound

HRID 1489162Notes

Reaction equation

HRID 1489162 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:15][N:16](CC2C=CC=CC=2)CC2C=CC=CC=2)([CH2:13][F:14])[CH2:9]1)C1C=CC=CC=1.O.NN>C(O)C.[C].[Pd]>[NH2:16][CH2:15][C:10]1([CH2:13][F:14])[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22903694HCID 22903694, compound

Product 1

HCID 22903654HCID 22903654, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

1-Benzyl-3-(dibenzylaminomethyl)-3-fluoromethylpyrrolidine (4.55 g) was dissolved in ethanol (40 ml), and 10% palladium-carbon (1 g) and hydrazine monohydrate (2.15 g) were added. The mixture was refluxed for 1 hour. After the completion of the reaction, the catalyst was removed, and the mixture was concentrated to give the object compound as an oil.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. customAfter the completion of the reaction
  3. customthe catalyst was removed
  4. concentrationthe mixture was concentrated

Sources & evidence

ORD record
ord-30b3723d6fbf4e42bc4f62d496dad0e0
Source dataset
uspto-grants-1997_10
Patent number
US05677316

Reaction notes

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