Sodium borohydride → HCID 22878316, compound

HRID 1489357Notes

Reaction equation

HRID 1489357 reaction equation
[BH4-].[Na+].[C:3]([O:6][C@@H:7]1[C@@H:11]([CH:12]=[CH:13][C:14]([O:16][CH3:17])=[O:15])[O:10][C@@H:9]([N:18]2[CH:26]=[C:24]([CH3:25])[C:22](=[O:23])[NH:21][C:19]2=[O:20])[CH2:8]1)(=[O:5])[CH3:4]>C(O)(C)C>[C:3]([O:6][C@@H:7]1[C@@H:11]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[O:10][C@@H:9]([N:18]2[CH:26]=[C:24]([CH3:25])[C:22](=[O:23])[NH:21][C:19]2=[O:20])[CH2:8]1)(=[O:5])[CH3:4]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 54037330HCID 54037330, compound

Product 1

HCID 22878316HCID 22878316, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

About 0.39 g sodium borohydride was added to a cold (ice bath) stirred, mixture of 3.17 g of 3'-O-acetyl-5'-carbomethoxymethylene-5'-deoxythymidine in 95 ml isopropanol. The mixture was stirred at 0° C. under nitrogen atmosphere for half an hour, then at room temperature for an additional four and one half hours.

Workup

  1. stirringThe mixture was stirred at 0° C. under nitrogen atmosphere for half an hour
  2. waitat room temperature for an additional four and one half hours

Sources & evidence

ORD record
ord-cfdb019607f04c6ca6ae8c52676c4dc7
Source dataset
uspto-grants-1997_10
Patent number
US05677439

Reaction notes

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