Hydrochloric Acid → HCID 19350728, compound

HRID 1489503Notes

Reaction equation

HRID 1489503 reaction equation
C([NH:4][N:5]1[CH:9]=[C:8]([CH3:10])[N:7]([CH3:11])[C:6]1=[O:12])(=O)C.[ClH:13]>CO>[ClH:13].[NH2:4][N:5]1[CH:9]=[C:8]([CH3:10])[N:7]([CH3:11])[C:6]1=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22901843HCID 22901843, compound

Product 1

HCID 19350728HCID 19350728, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.8 g of 1-acetylamino-2,3-dihydro-3,4-dimethyl-2-oxo-1H-imidazole are suspended in 800 ml of methanol, and the suspension is then heated to 42°. At this temperature, 28 g of gaseous HCl are passed into the suspension in the course of 40 minutes, during which process the suspension turns into a solution and the temperature of the reaction mixture rises to 52°. The solution is concentrated on a rotary evaporator, the residue is stirred with a small amount of tetrahydrofuran, and the crystals which have precipitated are filtered off with suction and dried, yielding the title salt melting at 162°-165°.

Workup

  1. temperaturethe suspension is then heated to 42°
  2. customare passed into the suspension in the course of 40 minutes, during which process
  3. customrises to 52°
  4. concentrationThe solution is concentrated on a rotary evaporator
  5. customthe crystals which have precipitated
  6. filtrationare filtered off with suction
  7. customdried

Sources & evidence

ORD record
ord-f241dce410c8466593dab3dacdd2ac42
Source dataset
uspto-grants-1997_10
Patent number
US05679623

Reaction notes

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