HCID 16637516, compound → HCID 54719500, compound

HRID 1489531Notes

Reaction equation

HRID 1489531 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[S:22][C:9]2[C:10]([OH:21])=[C:11]([C:17](OC)=[O:18])[N:12]([CH3:16])[S:13](=[O:15])(=[O:14])[C:8]=2[CH:7]=1.[F:23][C:24]1[CH:41]=[CH:40][C:27]([O:28][C:29]2[O:33][C:32]([C:34]3[N:35]=[C:36]([NH2:39])[S:37][CH:38]=3)=[CH:31][CH:30]=2)=[CH:26][CH:25]=1>C1(C)C(C)=CC=CC=1>[F:23][C:24]1[CH:41]=[CH:40][C:27]([O:28][C:29]2[O:33][C:32]([C:34]3[N:35]=[C:36]([NH:39][C:17]([C:11]4[N:12]([CH3:16])[S:13](=[O:15])(=[O:14])[C:8]5[CH:7]=[C:6]([C:2]6[O:1][CH:5]=[CH:4][CH:3]=6)[S:22][C:9]=5[C:10]=4[OH:21])=[O:18])[S:37][CH:38]=3)=[CH:31][CH:30]=2)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 16637516HCID 16637516, compoundHCID 54719484HCID 54719484, compound

Product 1

HCID 54719500HCID 54719500, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

0.339 g (0.99 mmol) of methyl 6-(2-furanyl)-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylate 1,1-dioxide and 0.398 g (1.44 mmol) of 4-[5-(4-fluorophenoxy)-2-furanyl]-2-thiazolamine are heated to boiling in 3 ml of absolute xylene. After 4.5 h, the suspension is cooled, and the precipitated product is filtered off, digested several times with diethyl ether and recrystallized from dimethyl sulphoxide/acetone 10:1.

Workup

  1. temperaturethe suspension is cooled
  2. filtrationthe precipitated product is filtered off
  3. customrecrystallized from dimethyl sulphoxide/acetone 10:1

Sources & evidence

ORD record
ord-4d91effebba84ffeadf4cce24744aaca
Source dataset
uspto-grants-1997_10
Patent number
US05679678

Reaction notes

Loading…