Dicyclohexylcarbodiimide → N,N'-Dicyclohexylurea

HRID 1489762Notes

Reaction equation

HRID 1489762 reaction equation
CC([C@]1(O)[C@@]2(C)[C@]3(O)[C@]45O[C@@]2(O)C[C@@](C)([C@@]4(O)CCC([C@H]5[OH:19])=C)[C@]3(O)[C@@H]1OC(C1NC=CC=1)=O)C.IC1C=CC(C(NCCC(O)=O)=O)=CC=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.[CH:65]1([N:71]=[C:72]=[N:73][CH:74]2[CH2:79][CH2:78][CH2:77][CH2:76][CH2:75]2)[CH2:70][CH2:69][CH2:68][CH2:67][CH2:66]1>CN(C1C=CN=CC=1)C.C(Cl)Cl.O1CCCC1.O>[C:72]([NH:71][CH:65]1[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70]1)([NH:73][CH:74]1[CH2:79][CH2:78][CH2:77][CH2:76][CH2:75]1)=[O:19]

Participants

9

Reactant 4

HCID 10868Dicyclohexylcarbodiimide2×HCID 14812Phosphorus oxide (P4O10)HCID 1251684,6,7,8a,8b,9a-Hexahydroxy-6a,9-dimethyl-3-methylidene-7-(propan-2-yl)dodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylateHCID 22902432HCID 22902432, compound

Product 1

HCID 4277N,N'-Dicyclohexylurea

Reagents, catalysts & solvents 4

HCID 142844-(Dimethylamino)pyridineCatalystHCID 962WaterSolventHCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

Dehydroryanodine (100 mg, 0.2 mmol), N-(p-iodobenzoyl)-β-alanine (50 mg, 0.22 mmol) and DMAP (2 mg, 0.02 mmol), all dried over P2O5, were dissolved in a solvent mixture of CH2Cl2 (10 ml) and tetrahydrofuran (0.1 ml) dried over Molecular Sieve. To the stirred solution, dicyclohexylcarbodiimide (DCC, 52 mg., 0.25 mmol) was added at once and the stirred reaction maintained at room temperature for 6 hours. Water (0.1 ml) was added to inactivate excess DCC and stirring was continued for 30 minutes. The crystals of dicyclohexylurea thus formed were filtered off and washed twice with CH2Cl2.

Workup

  1. customdried over Molecular Sieve
  2. customthe stirred reaction

Sources & evidence

ORD record
ord-043b49f1757a40ab96e424958ca04ab9
Source dataset
uspto-grants-1997_10
Patent number
US05679701

Reaction notes

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