Methyl iodide → Methyl 3-acetyl-5-bromo-4-methoxybenzoate

HRID 1489802Notes

Reaction equation

HRID 1489802 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([Br:15])[C:13]=1[OH:14])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2].[C:16]([O-])([O-])=O.[K+].[K+].CI>CC(C)=O>[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([Br:15])[C:13]=1[O:14][CH3:16])[C:7]([O:9][CH3:10])=[O:8])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 15818980Methyl 3-acetyl-5-bromo-4-hydroxybenzoate

Product 1

HCID 22101060Methyl 3-acetyl-5-bromo-4-methoxybenzoate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1 eq. of methyl 3-acetyl-5-bromo-4-hydroxybenzoate (preparation, see Example 19) was reacted, in acetone, with 2.0 eq. of K2CO3 and 2.1 eq. of methyl iodide to give methyl 3-acetyl-5-bromo-4-methoxybenzoate. Colorless oil, MS (ES): 288 (M+1).

Sources & evidence

ORD record
ord-c69c1bbbd2a54f01ad510a4f1af6164e
Source dataset
uspto-grants-1997_10
Patent number
US05679712

Reaction notes

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