反应详情

In dimethylformamide was suspended 61.6 mg of sodium hydride at 0° C., and 590 mg of 5,6-dimethoxy-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]indazole was added thereto, followed by stirring for 30 minutes. To the mixture was added 290 mg of 3,4-dimethoxyphenylmethyl chloride. After 1.5 hours, 2.0 ml of water was added to the reaction mixture, followed by evaporation of the solvent. The residue was purified by silica gel column chromatography (chloroform:ethanol=20:1) and recrystallized from ethanol to yield 654 mg of the title compound.

1. customat 0° C.
2. waitAfter 1.5 hours
3. customfollowed by evaporation of the solvent
4. customThe residue was purified by silica gel column chromatography (chloroform:ethanol=20:1)
5. customrecrystallized from ethanol