Hydrochloric Acid → HCID 21481014, compound

HRID 1490328Notes

Reaction equation

HRID 1490328 reaction equation
[ClH:1].C([NH:5][CH2:6][CH2:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[C:18]1[N:19]([CH3:31])[C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([O:27][CH3:28])=[C:22]([O:29][CH3:30])[CH:21]=2)(=O)C>>[ClH:1].[NH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[CH:10][C:9]=1[C:18]1[N:19]([CH3:31])[C:20]2[C:25]([CH:26]=1)=[CH:24][C:23]([O:27][CH3:28])=[C:22]([O:29][CH3:30])[CH:21]=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21481001HCID 21481001, compound

Product 1

HCID 21481014HCID 21481014, compound

Procedure

A 2N hydrochloric acid solution of 53.0 g of 2-[2-(2-acetamidoethyl)-4,5-dimethoxyphenyl]-5,6-dimethoxy-1-methylindole was heated under reflux for 17 hours. The reaction mixture was azeotropically distilled under reduced pressure with ethanol and benzene, and the residue was recrystallized from ethanol to yield 48 g of the title compound.

Workup

  1. temperatureunder reflux for 17 hours
  2. distillationThe reaction mixture was azeotropically distilled under reduced pressure with ethanol and benzene
  3. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-d95c82e77ce549719585bdda4a2d1391
Source dataset
uspto-grants-1997_10
Patent number
US05681954

Reaction notes

Loading…