Hydrochloric Acid → HCID 53666096, compound

HRID 1490368Notes

Reaction equation

HRID 1490368 reaction equation
C([NH:4][CH:5]1[CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:14]3[C:19]([C:20]([C:22]4[C:23]([C:28]5[CH:29]=[C:30]6[C:34](=[CH:35][CH:36]=5)[CH2:33][CH:32]([NH:37]C(=O)C)[CH2:31]6)=[N:24][CH:25]=[CH:26][CH:27]=4)=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:11]=2)[CH2:6]1)(=O)C.Cl>>[NH2:37][CH:32]1[CH2:31][C:30]2[C:34](=[CH:35][CH:36]=[C:28]([C:23]3[C:22]([C:20]([C:19]4[C:14]([C:10]5[CH:11]=[C:12]6[C:7](=[CH:8][CH:9]=5)[CH2:6][CH:5]([NH2:4])[CH2:13]6)=[N:15][CH:16]=[CH:17][CH:18]=4)=[O:21])=[CH:27][CH:26]=[CH:25][N:24]=3)[CH:29]=2)[CH2:33]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 544891472-Acetylamino-indan-5-yl-3-pyridyl ketone

Product 1

HCID 53666096HCID 53666096, compound

Procedure

51 g of 2-acetylamino-indan-5-yl-3-pyridyl ketone are refluxed for 16 hours with 250 ml of half concentrated hydrochloric acid. The solution is concentrated and then adjusted to pH 12 using 15N sodium hydroxide solution. The precipitate formed is washed with water and recrystallised from 100 ml of isopropanol.

Workup

  1. concentrationThe solution is concentrated
  2. customThe precipitate formed
  3. washis washed with water
  4. customrecrystallised from 100 ml of isopropanol

Sources & evidence

ORD record
ord-5cf9a7c88d434658bfabdc3d0eb0ba8d
Source dataset
uspto-grants-1997_10
Patent number
US05681961

Reaction notes

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