HRID1490369

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7397

p-Toluenesulfonyl chloride

C7H7ClO2S

HCID8471

Triethylamine

C6H15N

结构：NC1Cc2ccc(-c3ncccc3C(=O)c3cccnc3-c3ccc4c(c3)CC(N)C4)cc2C1

HCID53666096

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)NC2Cc3ccc(-c4ncccc4C(=O)c4cccnc4-c4ccc5c(c4)CC(NS(=O)(=O)c4ccc(C)cc4)C5)cc3C2)cc1

HCID54574482

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

21 g of 2-aminoindan-5-yl-3-pyridyl ketone are dissolved together with 18.9 g of p-toluenesulphonic acid chloride in 250 ml of methylene chloride. Then 9.2 g of triethylamine are added dropwise. After 4 hours the suspension is rotary-evaporated to dryness. The residue is suspended in water, made alkaline with sodium hydroxide solution and then suction filtered.

WORKUP

后处理

customAfter 4 hours the suspension is rotary-evaporated to dryness
filtrationsuction filtered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f1767b3a14f44f18963eeaa41567c883
来源数据集: uspto-grants-1997_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05681961
来源说明: uspto-grants-1997_10

反应 SMILES

[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]3[C:16]([C:17]([C:19]4[C:20]([C:25]5[CH:26]=[C:27]6[C:31](=[CH:32][CH:33]=5)[CH2:30][CH:29]([NH2:34])[CH2:28]6)=[N:21][CH:22]=[CH:23][CH:24]=4)=[O:18])=[CH:15][CH:14]=[CH:13][N:12]=3)[CH:8]=2)[CH2:3]1.[C:35]1([CH3:45])[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[CH:37][CH:36]=1.C(N([CH2:51][CH3:52])CC)C>C(Cl)Cl>[C:35]1([CH3:45])[CH:40]=[CH:39][C:38]([S:41]([NH:34][CH:29]2[CH2:28][C:27]3[C:31](=[CH:32][CH:33]=[C:25]([C:20]4[C:19]([C:17]([C:16]5[C:11]([C:7]6[CH:8]=[C:9]7[C:4](=[CH:5][CH:6]=6)[CH2:3][CH:2]([NH:1][S:41]([C:38]6[CH:39]=[CH:40][C:51]([CH3:52])=[CH:36][CH:37]=6)(=[O:43])=[O:42])[CH2:10]7)=[N:12][CH:13]=[CH:14][CH:15]=5)=[O:18])=[CH:24][CH:23]=[CH:22][N:21]=4)[CH:26]=3)[CH2:30]2)(=[O:43])=[O:42])=[CH:37][CH:36]=1