Benzoic acid, 2,6-difluoro-, ethyl ester → HCID 135741291, compound

HRID 1490726Notes

Reaction equation

HRID 1490726 reaction equation
CCOC(=O)c1c(F)cccc1F>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC(C)(C)O.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].O=c1ccc2cccc(-c3ccc(-c4ccccn4)nc3)c2[nH]1.[Ir].[Ir].[K]>CCOC(=O)c1c(F)cc(B2OC(C)(C)C(C)(C)O2)cc1F

Participants

7

Reactant 1

HCID 519631Benzoic acid, 2,6-difluoro-, ethyl ester

Product 1

HCID 135741291HCID 135741291, compoundYield 72%

Reagents, catalysts & solvents 5

HCID 2733548Bis(pinacolato)diboraneReagentHCID 86639980Potassium tert-butoxideReagentHCID 1646813858-([2,2'-bipyridin]-5-yl)quinolin-2(1H)-oneReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Sources & evidence

ORD record
ord-4aff66f8407141d993b8d6379d76d4e9
Source dataset
Borylation dataset from Roche

Reaction notes

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