huagongshe.com
HRID1490907

反应详情

EQUATION

反应方程式

HRID 1490907 的结构方程式

REACTANTS

反应物

1
结构：Cc1ccc2cc(Cl)ccc2n1
HCID135965

6-Chloroquinaldine

C10H8ClN

PRODUCTS

生成物

1
结构：Cc1cc(B2OC(C)(C)C(C)(C)O2)c2cc(Cl)ccc2n1
HCID178422402

未命名化合物

收率 79%

AUXILIARIES

试剂、催化剂与溶剂

4
结构：CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C
试剂HCID2733548

Bis(pinacolato)diboron

C12H24B2O4

结构：CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1
试剂HCID4249187

未命名化合物

结构：C1=CCCC=CCC1.C1=CCCC=CCC1.C[OH2+].C[OH2+].[Ir].[Ir]
催化剂HCID76001521

未命名化合物

结构：COC(C)(C)C
溶剂HCID15413

Methyl tert-butyl ether

C5H12O

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

General procedure A was applied to 2-methyl-6-chloroquinoline (177 mg, 1.00mmol). Purification by silica gel flash-column chromatography with gradient elution of MeOH/DCM from 0.5 -12.5% over 25 column volumes, affording 6-chloro-2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)quinoline as a white solid (239 mg, 79%); m.p.105 -106 °C;