N,N-Dimethyl-3-(methylsulfanyl)aniline → HCID 178503074, compound

HRID 1491143Notes

Reaction equation

HRID 1491143 reaction equation
CSc1cccc(N(C)C)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.C[OH2+].C[OH2+].Cc1ccc(C)cc1.Cc1ccnc(-c2cc(C)ccn2)c1.[Ir].[Ir]>CSc1cc(B2OC(C)(C)C(C)(C)O2)cc(N(C)C)c1

Participants

6

Reactant 1

HCID 20403482N,N-Dimethyl-3-(methylsulfanyl)aniline

Product 1

HCID 178503074HCID 178503074, compoundYield 63%

Reagents, catalysts & solvents 4

HCID 143384,4'-Dimethyl-2,2'-bipyridineReagentHCID 2733548Bis(pinacolato)diboraneReagentHCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridiumCatalystHCID 7809P-XyleneSolvent

Conditions

Temperature
55 °C

Procedure

dtbpy: A mixture of ortho- and meta-borylated products (92 mg, 63% yield, ortho/meta + para = <0.01); meta-Isomer (5h) were obtained by further purification by GPC (88 mg, 60% yield), yellow solid;

Sources & evidence

ORD record
ord-cbd110ca6fe34a4493b2b9b6dfbb496c
Source dataset
Borylation dataset from Roche

Reaction notes

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