Hydrochloric Acid → HCID 18953932, compound

HRID 1491843Notes

Reaction equation

HRID 1491843 reaction equation
[NH2:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]2[N:10]=[C:11]([N:14]=[C:15]([NH2:17])[NH2:16])[S:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=1.[ClH:18].[O-:19][C:20]#[N:21].[K+].C(=O)([O-])[O-].[K+].[K+]>O>[ClH:18].[ClH:18].[NH2:16][C:15](=[N:14][C:11]1[S:12][CH:13]=[C:9]([C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([CH2:2][NH:1][C:20]([NH2:21])=[O:19])[N:8]=2)[N:10]=1)[NH2:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 103997684-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazoleHCID 11378442Potassium cyanate

Product 1

HCID 18953932HCID 18953932, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.64 g), 1N-hydrochloric acid (5.15 ml) and potassium cyanate (0.21 g) in water (6.4 ml) was stirred for 19 hours at ambient temperature. The solution was made basic with aqueous potassium carbonate and the resulting precipitate was collected by filtration. The free base was converted to the hydrochloride in a usual manner followed by recrystallization from aqueous methanol to give 2-(diaminomethyleneamino)-4-(6-ureidomethylpyridin-2-yl)thiazole dihydrochloride (0.45 g).

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. customfollowed by recrystallization from aqueous methanol

Sources & evidence

ORD record
ord-8a0eb7483dee4b3ab0a0991e5b5b3783
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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