Triethylamine → 2-(Diaminomethyleneamino)-4-[2-(2-cyano-3-methylguanidino)methylthiazol-4-yl]thiazole
Reaction equation
Cl.Cl.[NH2:3][CH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[N:11]=[C:12]([N:15]=[C:16]([NH2:18])[NH2:17])[S:13][CH:14]=2)[N:9]=1.[C:19]([N:21]=[C:22](SC)SC)#[N:20].[CH2:27]([N:29](CC)CC)C>CN(C)C=O>[NH2:17][C:16](=[N:15][C:12]1[S:13][CH:14]=[C:10]([C:8]2[N:9]=[C:5]([CH2:4][NH:3][C:19]([NH:21][CH3:22])=[N:20][C:27]#[N:29])[S:6][CH:7]=2)[N:11]=1)[NH2:18]Participants
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A suspension of 4-(2-aminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole dihydrochloride (1.0 g), dimethyl N-cyanodithiocarbonimidate (0.45 g) and triethyl amine (0.7 g) in N,N-dimethylformamide (40 ml) was heated at 70° C. for 10 hours. 40% methylamino solution (5 ml) was added to the reaction mixture and the mixture was stirred at room temperature for 14 hours. The solvent was removed under reduced pressure. The residue was suspended in water (30 ml) and the mixture was alkalized to pH 10 with a saturated aqueous potassium carbonate solution. The resulting precipitate was collected by filtration. Recrystallization from a mixture of N,N-dimethylformamide and water afforded 2-(diaminomethyleneamino)-4-[2-(2-cyano-3-methylguanidino)methylthiazol-4-yl]thiazole (0.2 g).
Workup
- addition40% methylamino solution (5 ml) was added to the reaction mixture
- customThe solvent was removed under reduced pressure
- filtrationThe resulting precipitate was collected by filtration
- customRecrystallization
- additionfrom a mixture of N,N-dimethylformamide and water
Sources & evidence
- ORD record
- ord-db651b0f355e48bb90920c970de37a32
- Source dataset
- uspto-grants-1994_12
- Patent number
- US05371097
Reaction notes
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