Hydrochloric Acid → HCID 18953926, compound

HRID 1491873Notes

Reaction equation

HRID 1491873 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][C:12]1[S:13][CH:14]=[C:15]([C:17]2[N:18]=[C:19]([N:22]=[C:23]([NH2:25])[NH2:24])[S:20][CH:21]=2)[N:16]=1)=O)(C)(C)C>C(O)C>[ClH:1].[ClH:1].[NH2:9][CH2:10][CH2:11][C:12]1[S:13][CH:14]=[C:15]([C:17]2[N:18]=[C:19]([N:22]=[C:23]([NH2:25])[NH2:24])[S:20][CH:21]=2)[N:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18953788HCID 18953788, compound

Product 1

HCID 18953926HCID 18953926, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrogen chloride gas was babbled to a solution of 4-[2-(2-t-butoxycarbonylaminoethyl)thiazol-4-yl]-2-(diaminomethyleneamino)thiazole (3.0 g) in ethanol (30 ml) for 10 minutes at room temperature. The mixture was stirred at room temperature for 20 minutes. The resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol and diisopropyl ether afforded 4-[2-(2-aminoethyl)thiazol-yl]-2-(diaminomethyleneamino)thiazole dihydrochloride (2.3 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. customRecrystallization
  3. additionfrom a mixture of methanol and diisopropyl ether

Sources & evidence

ORD record
ord-08620f040e344ce0b1f91cced4ffcc3e
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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