Ethyl Acetate → HCID 18953851, compound

HRID 1491881Notes

Reaction equation

HRID 1491881 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([O:18]C)=O)[N:11]=2)[N:9]=1)[NH2:3].O.[NH2:21][NH2:22].C(OCC)(=O)C>C(O)C>[NH2:3][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([NH:21][NH2:22])=[O:18])[N:11]=2)[N:9]=1)[NH2:1]

Participants

5

Reactant 3

HCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 18953773HCID 18953773, compound

Product 1

HCID 18953851HCID 18953851, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(diaminomethyleneamino)-4-(6-methoxycarbonylpyridin-2-yl)thiazole (4.0 g) and 100% hydrazine monohydrate (1.05 ml) in ethanol (40 ml) was heated under reflux for 8 hours. To the reaction mixture was added ethyl acetate (60 ml) under stirring at ambient temperature. The isolated precipitate was collected by filtration to give 2-(diaminomethyleneamino)-4-(6-hydrazinocarbonylpyridin-2-yl)thiazole (3.19 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 8 hours
  3. filtrationThe isolated precipitate was collected by filtration

Sources & evidence

ORD record
ord-c0161d4b8c67440c84aba6a74674883b
Source dataset
uspto-grants-1994_12
Patent number
US05371097

Reaction notes

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