Water → HCID 18952362, compound

HRID 1492139Notes

Reaction equation

HRID 1492139 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:13])[CH:8]=[CH:9][C:10]=2[Cl:12])[N:5]=[CH:4][N:3]=1.O.C([O-])(O)=O.[Na+].[CH:20]([OH:23])([CH3:22])[CH3:21]>>[Cl:12][C:10]1[CH:9]=[CH:8][C:7]([OH:13])=[C:6]2[C:11]=1[C:2]([O:23][CH:20]([CH3:22])[CH3:21])=[N:3][CH:4]=[N:5]2

Participants

5

Reactant 4

HCID 962WaterHCID 3776IsopropanolHCID 516892Sodium BicarbonateHCID 18952355HCID 18952355, compound

Product 1

HCID 18952362HCID 18952362, compound

Procedure

A mixture of 4,5-dichloro-8-quinazolinol (3.0 g, 13.95 mmol) in isopropanol is heated at reflux for 30 minutes, cooled to room temperature and filtered to obtain a solid. The solid is mixed with water and saturated NaHCO3 solution. The resultant mixture is filtered and the filter cake is washed with water and dried to give the title product as an off-white solid, 1.71 g, mp 126°-126.5° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 30 minutes
  3. filtrationfiltered
  4. customto obtain a solid
  5. filtrationThe resultant mixture is filtered
  6. washthe filter cake is washed with water
  7. customdried

Sources & evidence

ORD record
ord-20548eab57af4c63839f14d2033730a8
Source dataset
uspto-grants-1994_12
Patent number
US05373011

Reaction notes

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