Tetrabutylammonium Hydroxide → HCID 131718268, compound

HRID 1492142Notes

Reaction equation

HRID 1492142 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[C:4]([N:13]([CH3:15])[CH3:14])=[N:5][CH:6]=[N:7]2.[OH-].[CH2:17]([N+:21]([CH2:30][CH2:31][CH2:32][CH3:33])([CH2:26][CH2:27][CH2:28][CH3:29])[CH2:22][CH2:23][CH2:24][CH3:25])[CH2:18][CH2:19][CH3:20]>ClCCl>[CH2:30]([N+:21]([CH2:17][CH2:18][CH2:19][CH3:20])([CH2:22][CH2:23][CH2:24][CH3:25])[CH2:26][CH2:27][CH2:28][CH3:29])[CH2:31][CH2:32][CH3:33].[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[C:4]([N:13]([CH3:15])[CH3:14])=[N:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 2723671Tetrabutylammonium HydroxideHCID 18952375HCID 18952375, compound

Product 1

HCID 131718268HCID 131718268, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 5-Chloro-4-(dimethylamino)-8-quinazolinol (0.45 g, 2.01 mmol) and a 40% tetrabutylammonium hydroxide solution (1.0 g, 1.54 mmol) in dichloromethane is stirred for 10 minutes at room temperature, washed sequentially with water and brine, dried over Na2SO4 and concentrated in vacuo to obtain the title product as a green oil, 0.35 g, which is identified by 1HNMR spectral analysis.

Workup

  1. washwashed sequentially with water and brine
  2. dry with materialdried over Na2SO4
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c7d78c9bae8442f19842c646a933454e
Source dataset
uspto-grants-1994_12
Patent number
US05373011

Reaction notes

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