HCID 53720908, compound → [2-(1H-imidazol-1-yl)ethyl]methylamine dihydrochloride

HRID 1492163Notes

Reaction equation

HRID 1492163 reaction equation
[CH2:1]([N:8]([CH2:10][CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)C)C1C=CC=CC=1.[H][H]>CO.[OH-].[OH-].[Pd+2]>[CH3:1][NH:8][CH2:10][CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

Participants

5

Reactant 2

HCID 53720908HCID 53720908, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 6483896[2-(1H-imidazol-1-yl)ethyl]methylamine dihydrochloride

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

The title compound of Step 11 (5.70 g, 26.5 mmol) was reacted with Pd(OH)2 /C in methanol at 60° with 60 psi of hydrogen for 4 hours. Filtration through Celite gave the title compound as a clear, colorless oil (3.46 g). The proton spectrum was consistent with the proposed structure.

Workup

  1. filtrationFiltration through Celite

Sources & evidence

ORD record
ord-ee5941b5e5e744adbf1de815787f5871
Source dataset
uspto-grants-1994_12
Patent number
US05373017

Reaction notes

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