2-Piperidone → HCID 178478132, compound

HRID 1492193Notes

Reaction equation

HRID 1492193 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]1=O.[NH2:8][C:9]1[CH:21]=[C:20]([Cl:22])[CH:19]=[CH:18][C:10]=1[CH2:11][N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[Cl:22][C:20]1[CH:19]=[CH:18][C:10]([CH2:11][N:12]2[CH2:13][CH2:14][O:15][CH2:16][CH2:17]2)=[C:9]([N:8]=[C:2]2[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]2)[CH:21]=1

Participants

5

Reactant 3

HCID 126652-PiperidoneHCID 24813Phosphorus oxychlorideHCID 18952306HCID 18952306, compound

Product 1

HCID 178478132HCID 178478132, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

A mixture of 2-piperidone (6 g) in benzene (50 ml), 4-(2-amino-4-chlorobenzyl)morpholine (6.8 g) in benzene (50 ml) and phosphorus oxychloride (5.5 ml) was heated at 60°-65° C. for 5 hours to give 4-[4-chloro-2-(2-piperidinylideneamino)benzyl]morpholine (m.p. 121°-122° C.) which was recrystallised from hexane.

Sources & evidence

ORD record
ord-2fa0f63fbe0a4e0cbd8430e645ed8505
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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