Dimethylformamide → HCID 15746398, compound

HRID 1492203Notes

Reaction equation

[OH:1][CH2:2][CH2:3][N:4]1[CH2:8]CNC1=O.[H-].[Na+].[CH3:12]I.[CH3:14][N:15]([CH3:18])[CH:16]=[O:17]>>[CH3:14][N:15]1[CH2:18][CH2:8][N:4]([CH2:3][CH2:2][O:1][CH3:12])[C:16]1=[O:17]

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 77290Hydroxyethyl imidazolidinone

Product 1

HCID 15746398HCID 15746398, compound

Procedure

Reaction of 1-(2-hydroxyethyl)-2-imidazolidinone (13 g) in dry dimethylformamide (125 ml) with sodium hydride (50% suspension in paraffin oil 12 g) at 10° C. for 3 hours was followed by treatment with methyl iodide (35.5 g) over a period of one hour. The mixture was stirred at ambient temperature for 18 hours gave 1-methyl-3-(2-methoxyethyl)-2-imidazolidinone (b.p. 110°-114° C. at 0.4 mm).

Sources & evidence

ORD record: ord-6a0acf853f704b7e8c1e0755f1cd0377
Source dataset: uspto-grants-1994_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05373008

Reaction notes

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