Phosphorus oxychloride → HCID 15746465, compound

HRID 1492208Notes

Reaction equation

HRID 1492208 reaction equation
[CH3:1][N:2]([CH3:11])[C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.P(Cl)(Cl)(Cl)=O>C1C=CC=CC=1>[CH3:1][N:2]([CH3:11])[C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[N:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

5

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 7357562-MorpholinoanilineHCID 3411496N,N-dimethylmorpholine-4-carboxamide

Product 1

HCID 15746465HCID 15746465, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Reaction of 4-dimethylcarbamoylmorpholine (3.8 g) in benzene (25 ml) with 4-(2-aminophenyl)morpholine (3.5 g) in the presence of phosphorus oxychloride (2.1 ml) for 40 hours at 80°-85° C. gave N,N-dimethyl-N'-(2-morpholinophenyl)morpholine-4-carboxamidine (m.p. 126°-128° C.) which was recrystallised from hexane.

Sources & evidence

ORD record
ord-1e28973a11e54a50a0b73bd272a63bde
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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