Methylamine → HCID 178484905, compound

HRID 1492237Notes

Reaction equation

HRID 1492237 reaction equation
I.CS[C:4](=[N:18][CH3:19])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:20][NH2:21]>C(O)C>[CH3:19][NH:18][C:4]([NH:21][CH3:20])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 18952225HCID 18952225, compound

Product 1

HCID 178484905HCID 178484905, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-1-(2-morpholinophenyl)-3-methyl-2-thiopseudourea hydroiodide (3.9 g) and 33% methylamine in solution in absolute ethanol (40 ml) was heated for 28 hours at 50°-55° C. to yield 1,3-dimethyl-2-(2-morpholinophenyl)guanidine which was recrystallised from hexane (m.p. 137°-138° C.).

Workup

  1. temperaturewas heated for 28 hours at 50°-55° C.

Sources & evidence

ORD record
ord-7d55e7a0d79d460593b1e886c05916cb
Source dataset
uspto-grants-1994_12
Patent number
US05373008

Reaction notes

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